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KMID : 1034320150060020060
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Sleep Medicine Research
2015 Volume.6 No. 2 p.60 ~ p.65
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Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults
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:Lee Jung-Hie
:Kim Seong-Jae/:Lee Se-Yong/:Hwang Jun-Won/:Suh In-Bum
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Abstract
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Background and Objective: Individuals have a unique circadian preference, which is based on differences in endogenous rhythm and environmental factors. There has been no study on the relationship between the morningness-eveningness (ME) preference and the polymorphisms of PER2 and CRY1 genes, which may play an essential role in the modulation of circadian rhythm. Our present study aims to examine the difference in the polymorphisms of PER2-2221A/G and CRY1-2790T/G, which are related to a greater cancer risk, according to the ME preference.
Methods: The Korean version of the Morningness-Eveningness Questionnaire was administered and buccal DNA samples were obtained from 425 Korean adults aged 18 years or older. We excluded subjects who were being treated for sleep disorders or those with shift work. 47 morning type (MT) (age: 44.57 ± 12.33, M:F = 14:33) subjects, 59 neither type (NT) (age: 35.20 ± 9.53, M:F = 20:39) subjects and 51 evening type (ET) (age: 28.80 ± 8.03, M:F = 14:37) subjects were finally included in the present study. The above candidate single nucleotide polymorphisms were analyzed by DNA sequencing or a SNaPshot assay.
Results: For the PER2-2221A/G and CRY1-2790T/G, there were no significant differences in the genotype distribution, allele frequency, or proportion of G allele positive subjects between the MT and ET groups. There was no significant difference in the mean scores of the MEQ-K, KESS, or PSQI between G allele positive and negative subjects for either PER2-A2221A/G or CRY1-2790T/G.
Conclusions: Our study did not support the association of the ME preference with the PER2-2221 A/G and CRY1-2790T/G in Korean adults.
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KEYWORD
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Morningness-eveningness, Cancer risk, PER2-2221A/G, CRY1- 2790T/G, Korean adults
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